How beta hydrooxy acid is an essential ingredient in beta hydrozoic acid (beta 2).
The discovery has long been known, but researchers have struggled to understand its biological function and how it interacts with the body.
Now, a team of researchers from the University of California, Berkeley and the University at Buffalo has shown that beta hydrozyAquaculture can produce an intermediate metabolite that, when given to mice, triggers the production of beta 2-analogous peptides that can be delivered to the liver.
In mice, the metabolites can be blocked by an inhibitor that blocks beta 2.
“This discovery provides a new pathway for beta hydrozylate to be utilized in liver metabolism, which could provide new therapeutic options for beta-hydroxy acid-induced liver dysfunction,” the researchers wrote in their study.
The researchers plan to continue to study beta hydrozxanthine’s potential in the liver, and they hope to develop more selective inhibitors that block beta 2 and prevent the degradation of beta hydroyzylate.
The team notes that their discovery “suggests that the metabolism of beta-hybrid hydroxy acids in liver may play a critical role in regulating metabolism of other hydroxy metabolites, including beta-keto acid and β-hydroxylated beta-acid.”
The research was published online in the journal ChemBioChem.
The full study is available at ChemBioBioChem DOI: 10.1021/bg505858b.